Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality (2024)

Lassen, T. H., Frederiksen, H., Jensen, T. K., Petersen, J. H., Joensen, U. N., Main, K. M., Skakkebaek, N. E., Juul, A., Jørgensen, N. (2014). Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality. Environmental Health Perspectives, 122(5), 478-84. https://doi.org/10.1289/ehp.1307309

Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality. / Lassen, Tina Harmer; Frederiksen, Hanne; Jensen, Tina Kold et al.
In: Environmental Health Perspectives, Vol. 122, No. 5, 05.2014, p. 478-84.

Research output: Contribution to journal › Journal article › Research › peer-review

Lassen, TH, Frederiksen, H, Jensen, TK, Petersen, JH, Joensen, UN, Main, KM, Skakkebaek, NE, Juul, A, Jørgensen, N 2014, 'Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality', Environmental Health Perspectives, vol. 122, no. 5, pp. 478-84. https://doi.org/10.1289/ehp.1307309

Lassen TH, Frederiksen H, Jensen TK, Petersen JH, Joensen UN, Main KM et al. Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality. Environmental Health Perspectives. 2014 May;122(5):478-84. doi: 10.1289/ehp.1307309

Lassen, Tina Harmer ; Frederiksen, Hanne ; Jensen, Tina Kold et al. / Urinary bisphenol A levels in young men : association with reproductive hormones and semen quality. In: Environmental Health Perspectives. 2014 ; Vol. 122, No. 5. pp. 478-84.

@article{661069ae1d9d4a38be7812bff0b23387,

title = "Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality",

abstract = "BACKGROUND: Few human studies have examined bisphenol A (BPA) exposure in relation to semen quality and reproductive hormones in men, and results are divergent.OBJECTIVES: We examined associations between urinary BPA concentration and reproductive hormones, as well as semen quality, in young men from the general population.METHODS: Our study population consisted of 308 young men from the general population. Urinary BPA concentration was measured by isotope dilution TurboFlow-liquid chromatography-tandem mass spectrometry. We used multiple linear regression analysis to estimate associations between BPA concentration and reproductive hormones and semen quality, adjusting for confounding factors.RESULTS: We found that 98% of the men had detectable urinary levels of BPA. Median (5th-95th percentiles) BPA concentration was 3.25 ng/mL (0.59-14.89 ng/mL). Men with BPA concentrations above the lowest quartile had higher concentrations of serum testosterone, luteinizing hormone (LH), estradiol, and free testosterone compared with the lowest quartile (p trend ≤ 0.02). Men in the highest quartile of BPA excretion had on average 18% higher total testosterone (95% CI: 8, 28%), 22% higher LH (95% CI: 6, 39%), and 13% higher estradiol (95% CI: 4, 24%) compared with lowest quartile. Men in the highest quartile of BPA also had significantly lower percentage progressive motile spermatozoa compared with men in the lowest quartile (-6.7 percentage points, 95% CI: -11.76, -1.63). BPA was not associated with other semen parameters. Adjusting for dietary patterns did not influence the results.CONCLUSIONS: The pattern of associations between BPA and reproductive hormones could indicate an antiandrogenic or antiestrogenic effect, or both, of BPA on the hypothalamic-pituitary-gonadal hormone feedback system, possibly through a competitive inhibition at the receptor level. However, additional research is needed to confirm our findings and to further test the suggested potential mechanisms.",

keywords = "Benzhydryl Compounds, Estradiol, Humans, Luteinizing Hormone, Male, Phenols, Semen, Semen Analysis, Testosterone",

author = "Lassen, {Tina Harmer} and Hanne Frederiksen and Jensen, {Tina Kold} and Petersen, {J{\o}rgen Holm} and Joensen, {Ulla N} and Main, {Katharina M} and Skakkebaek, {Niels E} and Anders Juul and Niels J{\o}rgensen and Anna-Maria Andersson",

year = "2014",

month = may,

doi = "10.1289/ehp.1307309",

language = "English",

volume = "122",

pages = "478--84",

journal = "Environmental Health Perspectives",

issn = "0091-6765",

publisher = "U.S. Department of Health and Human Services National Institute of Environmental Health Sciences",

number = "5",

}

TY - JOUR

T1 - Urinary bisphenol A levels in young men

T2 - association with reproductive hormones and semen quality

AU - Lassen, Tina Harmer

AU - Frederiksen, Hanne

AU - Jensen, Tina Kold

AU - Petersen, Jørgen Holm

AU - Joensen, Ulla N

AU - Main, Katharina M

AU - Skakkebaek, Niels E

AU - Juul, Anders

AU - Jørgensen, Niels

AU - Andersson, Anna-Maria

PY - 2014/5

Y1 - 2014/5

N2 - BACKGROUND: Few human studies have examined bisphenol A (BPA) exposure in relation to semen quality and reproductive hormones in men, and results are divergent.OBJECTIVES: We examined associations between urinary BPA concentration and reproductive hormones, as well as semen quality, in young men from the general population.METHODS: Our study population consisted of 308 young men from the general population. Urinary BPA concentration was measured by isotope dilution TurboFlow-liquid chromatography-tandem mass spectrometry. We used multiple linear regression analysis to estimate associations between BPA concentration and reproductive hormones and semen quality, adjusting for confounding factors.RESULTS: We found that 98% of the men had detectable urinary levels of BPA. Median (5th-95th percentiles) BPA concentration was 3.25 ng/mL (0.59-14.89 ng/mL). Men with BPA concentrations above the lowest quartile had higher concentrations of serum testosterone, luteinizing hormone (LH), estradiol, and free testosterone compared with the lowest quartile (p trend ≤ 0.02). Men in the highest quartile of BPA excretion had on average 18% higher total testosterone (95% CI: 8, 28%), 22% higher LH (95% CI: 6, 39%), and 13% higher estradiol (95% CI: 4, 24%) compared with lowest quartile. Men in the highest quartile of BPA also had significantly lower percentage progressive motile spermatozoa compared with men in the lowest quartile (-6.7 percentage points, 95% CI: -11.76, -1.63). BPA was not associated with other semen parameters. Adjusting for dietary patterns did not influence the results.CONCLUSIONS: The pattern of associations between BPA and reproductive hormones could indicate an antiandrogenic or antiestrogenic effect, or both, of BPA on the hypothalamic-pituitary-gonadal hormone feedback system, possibly through a competitive inhibition at the receptor level. However, additional research is needed to confirm our findings and to further test the suggested potential mechanisms.

AB - BACKGROUND: Few human studies have examined bisphenol A (BPA) exposure in relation to semen quality and reproductive hormones in men, and results are divergent.OBJECTIVES: We examined associations between urinary BPA concentration and reproductive hormones, as well as semen quality, in young men from the general population.METHODS: Our study population consisted of 308 young men from the general population. Urinary BPA concentration was measured by isotope dilution TurboFlow-liquid chromatography-tandem mass spectrometry. We used multiple linear regression analysis to estimate associations between BPA concentration and reproductive hormones and semen quality, adjusting for confounding factors.RESULTS: We found that 98% of the men had detectable urinary levels of BPA. Median (5th-95th percentiles) BPA concentration was 3.25 ng/mL (0.59-14.89 ng/mL). Men with BPA concentrations above the lowest quartile had higher concentrations of serum testosterone, luteinizing hormone (LH), estradiol, and free testosterone compared with the lowest quartile (p trend ≤ 0.02). Men in the highest quartile of BPA excretion had on average 18% higher total testosterone (95% CI: 8, 28%), 22% higher LH (95% CI: 6, 39%), and 13% higher estradiol (95% CI: 4, 24%) compared with lowest quartile. Men in the highest quartile of BPA also had significantly lower percentage progressive motile spermatozoa compared with men in the lowest quartile (-6.7 percentage points, 95% CI: -11.76, -1.63). BPA was not associated with other semen parameters. Adjusting for dietary patterns did not influence the results.CONCLUSIONS: The pattern of associations between BPA and reproductive hormones could indicate an antiandrogenic or antiestrogenic effect, or both, of BPA on the hypothalamic-pituitary-gonadal hormone feedback system, possibly through a competitive inhibition at the receptor level. However, additional research is needed to confirm our findings and to further test the suggested potential mechanisms.

KW - Benzhydryl Compounds

KW - Estradiol

KW - Humans

KW - Luteinizing Hormone

KW - Male

KW - Phenols

KW - Semen

KW - Semen Analysis

KW - Testosterone

U2 - 10.1289/ehp.1307309

DO - 10.1289/ehp.1307309

M3 - Journal article

C2 - 24786630

SN - 0091-6765

VL - 122

SP - 478

EP - 484

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

IS - 5

ER -